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KMID : 0624620150480070388
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BMB Reports
2015 Volume.48 No. 7 p.388 ~ p.394
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Cell type-specific gene expression profiling in brain tissue: comparison between TRAP, LCM and RNA-seq
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Kim Tae-Hyun
Lim Chae-Seok
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Abstract
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The brain is an organ that consists of various cell types. As our knowledge of the structure and function of the brain progresses, cell type-specific research is gaining importance. Together with advances in sequencing technology and bioinformatics, cell type-specific transcriptome studies are providing important insights into brain cell function. In this review, we discuss 3 different cell type-specific transcriptome analyses i.e., Laser Capture Microdissection (LCM), Translating Ribosome Affinity Purification (TRAP)/RiboTag, and single cell RNA-Seq, that are widely used in the field of neuroscience.
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KEYWORD
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Brain, Cell type-specific, Gene expression profiling, Neuron, Transcriptome
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